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cosinor analysis and two-way anova  (GraphPad Software Inc)


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    GraphPad Software Inc cosinor analysis and two-way anova
    Cosinor Analysis And Two Way Anova, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cosinor+analysis/cosinor+analysis+and+two+way+anova/pm40468648-916-3-11
    Average 90 stars, based on 1 article reviews
    cosinor analysis and two-way anova - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Comparison:

    Article Title: Nuclear magnetic resonance affects the circadian clock and hypoxia-inducible factor isoforms in zebrafish
    Article Snippet: .. Cosinor analysis: To test for the presence of circadian rhythms, we used GraphPad Prism version 6.00 for Windows (GraphPad Software, La Jolla, CA, USA, www.graphpad.com) and fit the data to two alternative regression models, either a straight line as null hypothesis or a circadian damped cosine curve as alternative hypothesis, defined by the following equation: Y = ((m×X) + C)+ amplitude × exp(–k × X)×cos(((2 × pi × (X-phase))/period)) The extra sum-of-squares F test was used for comparison of both models and the presence of a circadian rhythm was considered when p ≤ 0.05. ..

    Activity Assay:

    Article Title: Constant light and pinealectomy disrupt daily rhythm in song production and negatively impact reproductive performance in zebra finches.
    Article Snippet: We assessed the circadian clock control of singing and reproductive performance in zebra finches.. Experiment 1 examined changes in body mass, testis size, and plasma corticosterone and testosterone levels in male birds exposed to constant light (LL, 100 lx) and constant darkness (DD, 0.5 lx), with controls on 12L:12D (L = 100 lx, D = 0.5 lx).. There was a significant increase in the body mass and testis size under LL and a decrease in testis size under the DD.

    other:

    Article Title: Age- and time-of-day dependence of glymphatic function in the human brain measured via two diffusion MRI methods
    Article Snippet: Except for the cosinor analysis, all statistical analyses were performed in GraphPad Prism 8.

    Software:

    Article Title: Neutrophils instruct homeostatic and pathological states in naive tissues
    Article Snippet: To induce defective migration in various mutant mice, we injected mice intravenously with 25 μg of control rIgG or anti–P- and anti–E-selectin antibodies (clones RB40.34 and 9A9 from BioXcell, respectively) at days −5, −3, and −1 at ZT2. .. We used the Cosinor analysis ( ) to test for cyclical rhythmicity for a defined period of 24 h using the Graphpad Prism software. ..

    Expressing:

    Article Title: "Effect of time-restricted feeding on high-fat diet-induced metabolic dysfunction in Drosophila melanogaster".
    Article Snippet: Background: Metabolic alterations associated with obesity have been related to chronodisruption i.e., the desynchronization of molecular clocks that regulate circadian rhythms.. The search for tools that improve the dietary treatment of obesity has recently focused on behaviors related to chronodisruption, and intermittent fasting is increasingly gaining interest.. Studies in animal models have identified the benefits of time-restricted feeding (TRF) on metabolic alterations associated with changes in circadian rhythms induced by a high-fat diet.



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    A – C Bar chart of 6-, 12- and 18-month urinary, and 12- and 18-month plasma metabolites that follow a seasonal waveform based upon month of birth, from <t>cosinor</t> analysis (plasma n = 199; urine 6-month n = 278; 12-month n = 270; 18-month n = 266; p < 0.05 & q < 0.15 following Benjamini-Hochberg correction at ≥ one sampling point by extra-sums-of-squares F -test; exact p -values are provided in Supplementary Data. , ). Color indicates birth season of peak abundance (September-November, red; December-February, blue; March-May, pink; June-August, yellow). Solid circle represents birth-month-dependent metabolites (±1.5-month difference between birth month of peak abundance at two sampling points), unfilled circle indicates sampling-month-dependent (>four-month difference). D Mean plasma choline concentration by birth month (bold line; n = 199) at 12 (gray) and 18 months (green) following cosine distribution (dashed line) with 95% CI overlaid (shaded). E Median 1 H NMR six-month urinary metabolic spectral profile ( n = 278). Metabolites identified to significantly fit cosine waveforms based upon birth month are colored by birth season of peak abundance. Urinary metabolite relative abundance obtained by integrating the area under spectral regions. F – J Examples of urinary metabolites at six months that follow a cosine distribution (dashed line) by birth month. Mean relative abundance with 95% CI overlaid (shaded). Source data are provided as a Source Data file. EPA, eicosapentaenoic acid; TMAO, trimethylamine N -oxide; 2-PY, N -methyl-2-pyridone-5-carboxamide; NMND, N -methyl nicotinamide; 2’-FL, 2’-fucosyllactose; 3’FL, 3-fucosyllactose; DMG, dimethylglycine.
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    Image Search Results


    A – C Bar chart of 6-, 12- and 18-month urinary, and 12- and 18-month plasma metabolites that follow a seasonal waveform based upon month of birth, from cosinor analysis (plasma n = 199; urine 6-month n = 278; 12-month n = 270; 18-month n = 266; p < 0.05 & q < 0.15 following Benjamini-Hochberg correction at ≥ one sampling point by extra-sums-of-squares F -test; exact p -values are provided in Supplementary Data. , ). Color indicates birth season of peak abundance (September-November, red; December-February, blue; March-May, pink; June-August, yellow). Solid circle represents birth-month-dependent metabolites (±1.5-month difference between birth month of peak abundance at two sampling points), unfilled circle indicates sampling-month-dependent (>four-month difference). D Mean plasma choline concentration by birth month (bold line; n = 199) at 12 (gray) and 18 months (green) following cosine distribution (dashed line) with 95% CI overlaid (shaded). E Median 1 H NMR six-month urinary metabolic spectral profile ( n = 278). Metabolites identified to significantly fit cosine waveforms based upon birth month are colored by birth season of peak abundance. Urinary metabolite relative abundance obtained by integrating the area under spectral regions. F – J Examples of urinary metabolites at six months that follow a cosine distribution (dashed line) by birth month. Mean relative abundance with 95% CI overlaid (shaded). Source data are provided as a Source Data file. EPA, eicosapentaenoic acid; TMAO, trimethylamine N -oxide; 2-PY, N -methyl-2-pyridone-5-carboxamide; NMND, N -methyl nicotinamide; 2’-FL, 2’-fucosyllactose; 3’FL, 3-fucosyllactose; DMG, dimethylglycine.

    Journal: Nature Communications

    Article Title: Birth season shapes the infant metabolome and development in Tanzania: a secondary explorative analysis of the early life interventions for childhood growth and development in Tanzania (ELICIT) trial

    doi: 10.1038/s41467-025-66268-9

    Figure Lengend Snippet: A – C Bar chart of 6-, 12- and 18-month urinary, and 12- and 18-month plasma metabolites that follow a seasonal waveform based upon month of birth, from cosinor analysis (plasma n = 199; urine 6-month n = 278; 12-month n = 270; 18-month n = 266; p < 0.05 & q < 0.15 following Benjamini-Hochberg correction at ≥ one sampling point by extra-sums-of-squares F -test; exact p -values are provided in Supplementary Data. , ). Color indicates birth season of peak abundance (September-November, red; December-February, blue; March-May, pink; June-August, yellow). Solid circle represents birth-month-dependent metabolites (±1.5-month difference between birth month of peak abundance at two sampling points), unfilled circle indicates sampling-month-dependent (>four-month difference). D Mean plasma choline concentration by birth month (bold line; n = 199) at 12 (gray) and 18 months (green) following cosine distribution (dashed line) with 95% CI overlaid (shaded). E Median 1 H NMR six-month urinary metabolic spectral profile ( n = 278). Metabolites identified to significantly fit cosine waveforms based upon birth month are colored by birth season of peak abundance. Urinary metabolite relative abundance obtained by integrating the area under spectral regions. F – J Examples of urinary metabolites at six months that follow a cosine distribution (dashed line) by birth month. Mean relative abundance with 95% CI overlaid (shaded). Source data are provided as a Source Data file. EPA, eicosapentaenoic acid; TMAO, trimethylamine N -oxide; 2-PY, N -methyl-2-pyridone-5-carboxamide; NMND, N -methyl nicotinamide; 2’-FL, 2’-fucosyllactose; 3’FL, 3-fucosyllactose; DMG, dimethylglycine.

    Article Snippet: Cosinor analysis was performed in MATLAB (version R2022b, MathWorks Inc.; Statistics and Machine Learning Toolbox; Optimization Toolbox).

    Techniques: Clinical Proteomics, Sampling, Concentration Assay

    A Mean monthly (shaded) and 8-year average rainfall (dashed line) in Haydom, Tanzania. B Mean monthly food insecurity (% mothers worried about food availability; black line; 95% CI shaded) reported over an 18-month period following enrollment. Annual patterns of rain and harvests highlighted (dry season, yellow; short rains, blue; long rains, green). C – E Lollipop plots displaying phase lags between peak food insecurity during birth year (January 2018) and the birth month of greatest plasma and urinary metabolite abundance at 6 ( n = 278), 12 ( n = 270) and 18 months ( n = 266; q < 0.05) from cross-correlation. Color indicates phase lag (>3 months, purple; ≤3 months, pink); shape indicates source (urine, triangle; plasma, circle), and size R 2 . Shaded area highlights birth-month-dependent metabolites. F Heatmap of 1- and 5-month breastmilk metabolites displaying seasonality based on sampling month from cosinor analysis (n = 292; q < 0.15). Colors indicate highest abundance sampling season (September-November, red; December-February, blue; March-May, pink; June-August, yellow). Values indicate phase lags (days) between peak food insecurity and peak metabolite abundance from cross-correlation ( q < 0.05). G) Bar chart visualizing log2 fold change of 1-month breastmilk metabolite expression by reported food insecurity at sampling (No n = 40; yes n = 14). Differences assessed by two-sided Wilcoxon test with Benjamini Hochberg correction for multiple testing ( q < 0.05; 2-fucosyllactose (2’FL) p = 0.0004; lacto- N -fucopentaose I (LNFP-1) p = 0.0006). Source data are provided as a Source Data file. FAD flavin adenine dinucleotide, FMN flavin mononucleotide, PLP pyridoxal phosphate, Nac nicotinic acid, Pa pantothenic acid, NAD nicotinamide adenine dinucleotide, NR nicotinamide riboside, PM pyridoxamine, PN pyridoxine, GABA γ-aminobutyric acid, 3’FL 3-fucosyllactose, NMND N -methylnicotinamide, EPA eicosapentaenoic acid, C18.2, octadecadienylcarnitine.

    Journal: Nature Communications

    Article Title: Birth season shapes the infant metabolome and development in Tanzania: a secondary explorative analysis of the early life interventions for childhood growth and development in Tanzania (ELICIT) trial

    doi: 10.1038/s41467-025-66268-9

    Figure Lengend Snippet: A Mean monthly (shaded) and 8-year average rainfall (dashed line) in Haydom, Tanzania. B Mean monthly food insecurity (% mothers worried about food availability; black line; 95% CI shaded) reported over an 18-month period following enrollment. Annual patterns of rain and harvests highlighted (dry season, yellow; short rains, blue; long rains, green). C – E Lollipop plots displaying phase lags between peak food insecurity during birth year (January 2018) and the birth month of greatest plasma and urinary metabolite abundance at 6 ( n = 278), 12 ( n = 270) and 18 months ( n = 266; q < 0.05) from cross-correlation. Color indicates phase lag (>3 months, purple; ≤3 months, pink); shape indicates source (urine, triangle; plasma, circle), and size R 2 . Shaded area highlights birth-month-dependent metabolites. F Heatmap of 1- and 5-month breastmilk metabolites displaying seasonality based on sampling month from cosinor analysis (n = 292; q < 0.15). Colors indicate highest abundance sampling season (September-November, red; December-February, blue; March-May, pink; June-August, yellow). Values indicate phase lags (days) between peak food insecurity and peak metabolite abundance from cross-correlation ( q < 0.05). G) Bar chart visualizing log2 fold change of 1-month breastmilk metabolite expression by reported food insecurity at sampling (No n = 40; yes n = 14). Differences assessed by two-sided Wilcoxon test with Benjamini Hochberg correction for multiple testing ( q < 0.05; 2-fucosyllactose (2’FL) p = 0.0004; lacto- N -fucopentaose I (LNFP-1) p = 0.0006). Source data are provided as a Source Data file. FAD flavin adenine dinucleotide, FMN flavin mononucleotide, PLP pyridoxal phosphate, Nac nicotinic acid, Pa pantothenic acid, NAD nicotinamide adenine dinucleotide, NR nicotinamide riboside, PM pyridoxamine, PN pyridoxine, GABA γ-aminobutyric acid, 3’FL 3-fucosyllactose, NMND N -methylnicotinamide, EPA eicosapentaenoic acid, C18.2, octadecadienylcarnitine.

    Article Snippet: Cosinor analysis was performed in MATLAB (version R2022b, MathWorks Inc.; Statistics and Machine Learning Toolbox; Optimization Toolbox).

    Techniques: Clinical Proteomics, Sampling, Expressing

    Representative example of core body temperature data from dementia patients. Panel A and Panel B indicate the diurnal rhythms of core body temperature in participants classified into Type 1 (#105) and Type 2 (#109) groups. The data were measured three times every 2 weeks (top: 16-Nov-2023, middle: 30-Nov-2023, bottom: 14-Dec-2023). The black and red lines indicate the original core body temperature data and the cosinor curves fitted to the data, respectively. The grey areas indicate the time when the participants laid in their bed.

    Journal: Biogerontology

    Article Title: Variety of sleep and circadian rhythms of elderly dementia patients living in group home residences

    doi: 10.1007/s10522-025-10280-5

    Figure Lengend Snippet: Representative example of core body temperature data from dementia patients. Panel A and Panel B indicate the diurnal rhythms of core body temperature in participants classified into Type 1 (#105) and Type 2 (#109) groups. The data were measured three times every 2 weeks (top: 16-Nov-2023, middle: 30-Nov-2023, bottom: 14-Dec-2023). The black and red lines indicate the original core body temperature data and the cosinor curves fitted to the data, respectively. The grey areas indicate the time when the participants laid in their bed.

    Article Snippet: The rhythmic parameters of CBT were determined via cosinor fitting analysis (Molcan bio Rxiv).

    Techniques: